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Moderate to severe pain

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Moderate to severe pain, Pain associated with myocardial infarction, Postoperative pain, Severe cancer pain

Oral
Moderate to severe pain

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Acute pulmonary oedema, Premedication in surgery

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Severe cancer pain, Severe pain

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Moderate to severe pain: Dose reduction needed. Buy Morphine sulfate, for sale online in AustraliaParenteral
Acute pulmonary oedema; Premedication in surgery; Severe pain; Severe cancer pain: Dose reduction needed.Intravenous
Moderate to severe pain; Pain associated with myocardial infarction; Postoperative pain; Severe cancer pain: Dose reduction needed.

Oral
Moderate to severe pain: Dose reduction needed.Parenteral
Acute pulmonary oedema; Premedication in surgery; Severe pain; Severe cancer pain: Dose reduction needed.Intravenous
Moderate to severe pain; Pain associated with myocardial infarction; Postoperative pain; Severe cancer pain: Dose reduction needed.

May be taken with or without food. May be taken w/ meals to reduce GI discomfort. Buy Morphine sulfate, for sale online in Australia

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Hypersensitivity. Respiratory depression, obstructive airway disease, paralytic ileus, acute hepatic disease, acute alcoholism, head injuries, increased intracranial pressure, excessive bronchial secretions, acute or severe bronchial asthma, heart failure secondary to chronic lung disease, delayed gastric emptying, GI obstruction, acute abdomen, circulatory shock. Concomitant use during or within 14 days of MAOI therapy.

Patient with hypovolaemia, CV disease (including acute MI), circulatory shock, adrenal insufficiency, Addison disease, biliary tract dysfunction, acute pancreatitis, delirium tremens, prostatic hyperplasia, urinary stricture, toxic psychosis, myasthenia gravis, mental health conditions (e.g. depression, anxiety, post-traumatic stress disorder), seizure, thyroid dysfunction, history of drug abuse or acute alcoholism, obese. Renal and severe hepatic impairment. Pregnancy and lactation. Buy Morphine sulfate, for sale online in Australia

Significant: CNS depression, orthostatic hypotension, severe hypotension, syncope constipation.
Blood and lymphatic system disorders: Anaemia.
Cardiac disorders: Bradycardia, palpitation, tachycardia.
Eye disorder: Blurred or double vision, miosis.
Gastrointestinal disorders: Abdominal pain, constipation, delayed gastric emptying, diarrhoea, dyspepsia, flatulence, nausea, vomiting, xerostomia, dry mouth, anorexia.
General disorders and administration site conditions: Asthenic conditions, hyperhidrosis, withdrawal syndrome.
Hepatobiliary disorders: Biliary colic, hypoesthesia, hypokalemia.
Metabolism and nutrition disorders: Anorexia. Buy Morphine sulfate, for sale online in Australia
Musculoskeletal and connective tissue disorders: Back pain.
Nervous system disorders: Dizziness, headache, paresthesia, paralytic ileus, myoclonus.
Psychiatric disorders: Anxiety, confusion, dependence, insomnia hallucination, euphoria, agitation, mood altered.
Renal and urinary disorders: Bladder spasm, oliguria, urinary retention.
Reproductive system and breast disorders: Decreased libido or potency (long term use).
Respiratory, thoracic and mediastinal disorders: Dyspnea, hypoxia, rigors, bronchospasm, pulmonary oedema.
Skin and subcutaneous tissue disorders: Pruritus, skin rash, urticaria, sweating.
Vascular disorders: Hypertension, facial flushing.
Potentially Fatal: Hypersensitivity. Respiratory depression. Buy Morphine sulfate, for sale online in Australia

Epidural/IM/IT/IV/Parenteral/PO/Rectal/SC: C (Prolonged use may cause neonatal opioid withdrawal syndrome.)

This drug may cause CNS depression, if affected, do not drive or operate machinery.

Monitor efficacy of pain control, vital signs, respiratory and mental status. Assess physical and/or psychological dependence. Monitor signs or symptoms of hypogonadism or hypoadrenalism.

Symptoms: Respiratory depression, pinpoint pupils, hypoxia, hypothermia, severe dizziness, severe drowsiness, hypotension, bradycardia, circulatory failure pulmonary oedema, severe nervousness or restlessness, hallucinations, convulsion (especially in infants and children); skeletal muscle flaccidity, cold and clammy skin. Management: Ensure adequate airway, ventilation and oxygenation. Administration of opioid antagonist e.g. naloxone may be given as an antidote.

Increased depressant effects with other CNS depressants (e.g. sedatives, hypnotics, general anaesthesia, phenothiazines, tranquilisers). May enhance the neuromuscular blocking action of skeletal muscle relaxants. Reduced analgesic effect with mixed agonist/antagonist opioid analgesics (e.g. buprenorphine, nalbuphine, pentazocine). Increased plasma concentrations with cimetidine. Reduced plasma concentration with rifampicin, ritonavir. Decreased therapeutic effect of diuretics. Increased plasma concentration with cisapride. Increased risk of orthostatic hypotension with antihypertensive agents. Increased risk of severe constipation and CNS depression with antidiarrhoeal agents
Potentially Fatal: Enhanced depressant effect with MAOIs. Buy Morphine sulfate, for sale online in Australia

Alcohol enhances the CNS depressant effect of morphine. Increased bioavailability with food (oral).

May interfere with gastric emptying studies and with hepatobiliary imaging using technetium Tc^99m diosfenin.

Description: Morphine, an opioid analgesic, is a phenanthrene derivative which acts mainly on the CNS and smooth muscles. It binds to opiate receptors in the CNS altering pain perception and response by modulating the descending inhibitory pathways from the brain. Analgesia, euphoria and dependence are thought to be due to its action at the µ-1 receptors while respiratory depression and inhibition of intestinal movements are due to action at the µ-2 receptors. Spinal analgesia is mediated by morphine agonist action at the κ receptor.
Onset: Approx 30 minutes (conventional tab); 5-10 minutes (IV). Buy Morphine sulfate, for sale online in Australia
Duration: 3-5 hours (immediate-release); 8-24 hours (extended-release tab/cap); 3-7 hours (supp); Up to 24 hours (single dose epidural or intrathecal).
Pharmacokinetics:
Absorption: Well absorbed from the gastrointestinal tract (oral) and into the blood (SC/IM). Increased bioavailability with food. Bioavailability: 17-33 % (oral). Time to peak plasma concentration: 1 hour (conventional tab, epidural); 3-4 hours (extended-release tab); 20-60 minutes (supp); 50-90 minutes (SC); 30-60 minutes (IM); 20 minutes (IV).
Distribution: Widely distributed throughout the body mainly in the kidneys, liver, lungs and spleen, with lower concentrations in the brain and muscles. Crosses the blood-brain barrier and placenta; enters breast milk. Volume of distribution: 1-6 L/kg. Plasma protein binding: Approx 35%.
Metabolism: Metabolised in the liver and gut via glucuronidation to produce morphine-3-glucoronide and morphine-6-glucoronide; undergoes extensive first-pass metabolism. Buy Morphine sulfate, for sale online in Australia
Excretion: Via urine [approx 60% (oral); approx 90% (parenteral)]; faeces (10%, as conjugates). Elimination half-life: Approx 2 hours (morphine); 2.4-6.7 hours (morphine-3-glucoronide).

Source: National Center for Biotechnology Information. PubChem Database. Morphine, CID=5288826, https://pubchem.ncbi.nlm.nih.gov/compound/Morphine (accessed on Jan. 23, 2020)

Store between 20-25°C. Protect from light and moisture.